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Inhaltsbereich

Werkmeister Group

Team members | Projects | Publications | Completed Theses

We are working on the identification and quantification of novel OCT imaging biomarkers

The unique imaging properties of the OCT technology provide an insight into morphological and functional parameters of various biological tissues.
Our focus is on the design and implementation of both imaging devices and data evaluation methods for the assessment of these biomarkers and investigate their relevance in preclinical and clinical studies.

Here our research includes: Firstly, the morphological and functional imaging in the anterior eye segment, ranging from the assessment of the dynamics of the precorneal tear film and its lipid layer to the evaluation of the aqueous outflow system. Secondly, we measure functional parameters and properties like blood flow, oxygen extraction and neurovascular coupling in the retina and investigate its intrinsic optical signals. Not least, OCT and its functional extensions allow us to gain an insight into physiological processes during dermal woundhealing.

Research Area

Biophotonics

Research Topics

OCT Technologies | Translational OCT

Team Members

from left to right:
back: R. Werkmeister, V. Aranha dos Santos, H. Stegmann, M. Pfister
front: B.J. Schäfer, K. Schützenberger, A. Messner

Principal Investigator

Rene Werkmeister

PhD students

Alina Messner Martin Pfister Bhavapriya Schäfer Hannes Stegmann
Kornelia Schützenberger

Alumni

  • Gerold Aschinger
  • Valentin Aranha dos Santos
  • Thomas Blaschke
  • Michael Bronhagl
  • Veronika Doblhoff-Dier
  • Nikolaus Dragostinoff
           
  • Jószef Klaizer
  • Robert Klaus
  • Corinna Knopf
  • Iris Schmidt
  • Mozhgan Sharifizad
  • Martin Vietauer

Projects

2015-2019 In vivo optophysiology in humans using a novel laser interferometric approach (funded by Vienna Science, Research and Technology Fund (WWTF))
2014-2021 Christian Doppler Laboratory for Ocular and Dermal Effects of Thiomers

Publications

Complete List of Publications

  • Messner A, Werkmeister RM, Seidel G, Stegmann H, Schmetterer L, Aranha Dos Santos V, “Light-induced changes of the subretinal space of the temporal retina observed via optical coherence tomography”, Scientific Reports, Volume 9, Issue 1 (September 2019), doi: 10.1038/s41598-019-50057-8.
  • Stegmann H, Aranha dos Santos V, Messner A, Unterhuber A, Schmidl D, Garhoefer G, Schmetterer L, and Werkmeister RM,“Automatic assessment of tear film and tear meniscus parameters in healthy subjects using ultrahigh-resolution optical coherence tomography”, Biomed Opt Express, Volume 10, Issue 6 (May 2019), doi: 10.1364/BOE.10.002744
  • Aranha Dos Santos V, Schmetterer L, Stegmann H, Pfister M, Messner A, Schmidinger G, Garhofer G, Werkmeister RM, “CorneaNet: fast segmentation of cornea OCT scans of healthy and keratoconic eyes using deep learning”, Biomed Opt Exp, Volume 10, Issue 2 (January 2019), doi: 10.1364/BOE.10.000622
  • Werkmeister RM, Sapeta S, Schmidl D, Garhöfer G, Schmidinger G, Aranha dos Santos V, Aschinger GC, Baumgartner I, Pircher N, Schwarzhans F, Pantalon A, Dua H, Schmetterer L, “Ultrahigh-resolution OCT imaging of the human cornea”, Biomed Opt Exp, Vol 8, Issue 2 (February 2017), doi: 10.1364/BOE.8.001221
  • Aschinger GC, Schmetterer L, Fondi K, Aranha Dos Santos V, Seidel G, Garhöfer G, Werkmeister RM, “Effect of Diffuse Luminance Flicker Light Stimulation on Total Retinal Blood Flow Assessed With Dual-Beam Bidirectional Doppler OCT”, Invest Ophthalmol Vis Sci, Vol 58, Issue 2 (February 2017), doi: 10.1167/iovs.16-20598.
  • Werkmeister RM, Schmidl D, Aschinger G, Doblhoff-Dier V, Palkovits S, Wirth M, Garhöfer G, Linsenmeier RA, Leitgeb RA, Schmetterer L, “Retinal oxygen extraction in humans”, Scientific Reports, Vol 5 (October 2015), doi: 10.1038/srep15763.
  • Werkmeister RM, Vietauer M, Knopf C, Fürnsinn C, Leitgeb RA, Reitsamer H, Gröschl M, Garhöfer G, Vilser W, Schmetterer L, “Measurement of retinal blood flow in the rat by combining Doppler Fourier-domain optical coherence tomography with fundus imaging”, J Biomed Opt, Vol 19, Issue 10 (September 2014), doi: 10.1117/1.JBO.19.10.106008.
  • Leitgeb RA, Werkmeister RM, Blatter C, and Schmetterer L, “Doppler Optical Coherence Tomography”, Prog Retin Eye Res, Vol 41 (February 2014), doi: 10.1016/j.preteyeres.2014.03.004.
  • Werkmeister RM, Alex A, Kaya S, Unterhuber A, Hofer B, Riedl J, Bronhagl M, Vietauer M, Schmidl D, Schmoll T, Garhöfer G, Drexler W, Leitgeb RA, Groeschl M, Schmetterer L, “Measurement of tear film thickness using ultra-high resolution optical coherence tomography”, Invest Ophthalmol Vis Sci, Vol. 54, Issue 8 (August 2013), doi: 10.1167/iovs.13-11920.
  • Werkmeister RM, Dragostinoff N, Pircher M, Götzinger E, Hitzenberger CK, Leitgeb RA, and Schmetterer L, “Bidirectional Doppler Fourier-domain optical coherence tomography for measurement of absolute flow velocities in human retinal vessels”, Optics Letters, Vol. 33, Issue 24, pp. 2967-2969 (December 2008), doi: 10.1364/OL.33.002967.

    Completed Theses

    PhD theses

    • V. Aranha dos Santos, "Spectral domain optical coherence tomography for dynamic quantitative imaging of the anterior and posterior segment of the human eye", Doctoral Thesis (Vienna University of Technology, Vienna, Austria 2016)
    • G. Aschinger, "Dual-beam bidirectional Doppler Fourier domain optical coherence tomography for the characterization of the retinal vascular network perfusion", Doctoral Thesis (Vienna University of Technology, Vienna, Austria 2016)
    • M. Vietauer, “Assessment of retinal perfusion in the rat via Fourier-Domain Optical Coherence Tomography” (Vienna University of Technology, Vienna, Austria 2016)
    • V. Doblhoff-Dier "Determination of the Total Retinal Blood Flow Using Fourier-Domain Optical Coherence Tomography and Fundus Imaging", Doctoral Thesis (Vienna University of Technology, Vienna, Austria 2014)
    • R. Told "Impact of complement factor H polymorphism on choroidal and retinal blood flow regulation in healthy, young subjects", Doctoral Thesis PhD (Medical University of Vienna, Vienna, Austria 2013)
    • A. Boltz "Optic nerve head blood flow autoregulation during changes in ocular perfusion pressure and the role of endothelin-1“, Doctoral Thesis PhD (Medical University of Vienna, Vienna, Austria 2012)
    • R. M. Werkmeister, "Dual-beam Bidirectional Doppler Fourier-Domain Optical Coherence Tomography," Doctoral thesis (Medical University of Vienna, Vienna, Austria, 2010).
    • N. Dragostinoff, “Low coherence tissue interferometry for the depth-resolved measurement of ocular fundus pulsations,” Doctoral thesis (Vienna University of Technology, Vienna, Austria, 2010)


    Master and bachelor theses

    • Th. Blaschke, “Investigation of different detection approaches for measurement of blood flow velocities in retinal vessels of rodents” (Vienna University of Technology, Vienna, Austria 2017)
    • J. Klaizer, “Depth-Resolved Measurement of Ocular Fundus Pulsations in Rats using Low-Coherence Tissue Interferometry” (Vienna University of Technology, Vienna, Austria 2017)
    • Ch. Adleff, "Tracking labeled erythrocytes in the retina", Diploma thesis (Vienna University of Technology, Vienna, Austria 2014)
    • S. Caujolle "Building up of Thermal Light Source for Spectral Domain Optical Coherence Tomography (SD-OCT)", Master Thesis (Medical University of Vienna, Vienna, Austria 2014)
    • V. Aranha dos Santos, “Design and setup of a frequency domain optical coherence tomography system for measuring ocular fundus pulsations,” Master thesis (ERASMUS from Université Libre de Bruxelles, Brussels, Belgium 2012).
    • M. Bronhagl, “Noninvasive tear film measurement of the human eye using optical coherence tomography,” Master thesis (Vienna University of Technology, Vienna, Austria, 2012).
     
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