Inhaltsbereich
from left to right: W. Rohringer, T. Schmoll, A. J. Deloria, M. Niederleithner, Z. Chen, M. Andreana, L. Krainz, Q. Li, R. Haindl, L. Ginner, E. Rank, F. Placzek, L. Wurster, W. Drexler, H. Sattmann, R. Sentosa, A. Unterhuber, D. Bovenkamp, L. Ferrara, E. Brunner, R. Leitgeb, M. Salas, M. Liu, J. Püls
Leitgeb & Drexler Group
Advancing biomedical optical imaging for a step change in medical diagnostics as well as in fundamental biological and medical research
In order to accomplish the above goal our lab develops cutting edge optical technologies by combining strengths of different imaging modalities such as Optical Coherence Tomography (OCT), Photoacoustics, Fluorescence Microscopy, Raman Spectroscopy, and Non-linear Optical Microscopy. This is supported for example by advanced laser development, endoscope and laparoscope designs as well as photonics integrated circuits.
A key goal is the translation of the technologies to the clinics and to preclinical research by addressing imaging across the scales from the subcellular to the organ level.
Research Area
Research Topics
OCT Technologies | Translational OCT | Photoacoustics | Advanced Microscopy & Spectroscopy | Multimodal Biomedical Imaging
Team members
Group Leaders
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| Rainer Leitgeb | Wolfgang Drexler |
Principal Investigators
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| Marco Andreana | Mengyang Liu (on leave) | Angelika Unterhuber |
Postdocs
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| Elisabeth Brunner | Anton Grebenyuk | Qian Li | |
PhD students
Bachelor-/Master students
- Alice Kern
- Alexander Sing
Alumni
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Projects
Peer-reviewed funded ongoing projects from this group
- REAP (2021-2024) EU-H2020-ICT
- Phast (2020-2024) EU-H2020 - MSCA-ITN
- SWIMMOT (2020-2024) EU-H2020-FETOPEN-2018-2019-2020
- PROSCOPE (2019-2023) EU-H2020-ICT
- Handheld OCT (2020-2024) EU-H2020-ICT
- SkinOptima (2020-2023) EU-H2020-MSCA-IF-2019-Individual Fellowships
- Wavefront PAT/OCT (2019-2022) FWF SFB
- ESOTRAC (2017-2020) EU-H2020-ICT-29-2016-Photonics KET 2016
- MultiFib, (2019-2022) ERA-Net
- MIB (2016-2021) EU-H2020 - PHC-2015
- FBI (2016-2020) EU-H2020 - MSCA-ITN-2016
- MOON (2016-2021) EU-H2020 - ICT-2016-1
- Tomography across the scales (2018-2026) SFB - FWF
- Christian Doppler Laboratory for Innovative Optical Imaging and its Translation to Medicine (2016-2021)
- Digital Wavefront Sensing, (2017-2020) FWF
- Ultra-fast Scalable OCT (2018-2020) NIH (R21)
- OCT Chip (2015-2020) EU-H2020 - ICT-2015
Publications
Selected peer-reviewed publications
Complete List of Publications Drexler
Complete List of Publications Leitgeb
- Rank, E.A., Sentosa, R., Harper, D.J. et al. "Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings", Light Sci Appl 10, 6 (2021).
- W. Drexler, M. Liu, A. Kumar, T. Kamali, A. Unterhuber, and R. A. Leitgeb, 2014, "Optical coherence tomography today: speed, contrast, and multimodality," Journal of Biomedical Optics 19, 071412-071412.
- R. Haindl, et al., 2020. “Functional optical coherence tomography and photoacoustic microscopy imaging for zebrafish larvae,” Biomedical Optics Express, 11(4), 2137-2151.
- M. Liu, et al., 2019. “Optical coherence tomography angiography and photoacoustic imaging in dermatology,” Photochemical & Photobiological Sciences, 18(5), 945-962.
- Z. Chen, et al., 2017. “Non-invasive multimodal optical coherence and photoacoustic tomography for human skin imaging,” Scientific Reports, 7, 17975.
- R. Haindl, et al., 2017. “Dual modality reflection mode optical coherence and photoacoustic microscopy using an akinetic sensor,” Optics Letters, 42(21), 4319-4322.
- S. Preisser, et al., 2016. “All-optical highly sensitive akinetic sensor for ultrasound detection and photoacoustic imaging,” Biomedical Optics Express, 7(10), 4171-4186.
- L. Ginner, A. Kumar, D. Fechtig, L. M. Wurster, M. Salas, M. Pircher, and R. A. Leitgeb, 2017. "Noniterative digital aberration correction for cellular resolution retinal optical coherence tomography in vivo," Optica 4, 924-931.
- L. M. Wurster, R. N. Shah, F. Placzek, S. Kretschmer, M. Niederleithner, L. Ginner, J. Ensher, M. P. Minneman, E. E. Hoover, H. Zappe, W. Drexler, R. A. Leitgeb, and Ç. Ataman, 2019. "Endoscopic optical coherence tomography angiography using a forward imaging piezo scanner probe," Journal of Biophotonics 12, e201800382.
- D. Reichert, M.T. Erkkila, G. Holst, N. Hecker-Denschlag, M. Wilzbach, C. Hauger, W. Drexler, J. Gesperger, T. Roetzer, A. Unterhuber, G. Widhalm, M. Andreana, R. A. Leitgeb, 2020. “Towards real-time wide-field fluorescence lifetime imaging of 5-ALA labeled brain tumors with a dual-tap CMOS camera,” Biomedical Optics Express 11(3):1598-1616.
- M. Andreana, R. Sentosa, M.T. Erkkilä, W. Drexler, and A. Unterhuber, 2019, “Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue”, Photochem. Photobiol. Sci. 18, 997-1008.
- M. Andreana, T. Le, W. Drexler, and A. Unterhuber, 2019. “Ultrashort pulse Kagome hollow-core photonic crystal fiber delivery for nonlinear optical imaging”, Opt. Lett. 44 (7) 1588-1591.
- D. Bovenkamp, R. Sentosa, E. Rank, M. Erkkilä, F. Placzek, J. Püls, W. Drexler, R. Leitgeb, N. Garstka, S. Shariat, C. Stiebing, I.W. Schie, J Popp, M. Andreana and A. Unterhuber, 2018. “Combination of high-resolution optical coherence tomography and Raman spectroscopy for improved staging and grading in bladder cancer”, Appl. Sci. 8 (12), 2371.
Completed Theses
- Zhe Chen, „Multi-modal optical coherence tomography (OCT), OCT angiography and photoacoustic tomography for clinical in vivo three-dimensional cutaneous morphology and vasculature imaging” (PhD, Medical University of Vienna, 2020)
- Laurin Ginner, "Advanced techniques for functional parallel OCT" (PhD, Medical University of Vienna, 2019)
- Lara Marie Wurster, "Advanced techniques for endoscopic optical coherence tomography" (PhD, Medical University of Vienna, 2019)
- Zabihian, Behrooz, “Imaging human cutaneous morphology and microcirculation using photoacoustic / optical coherence tomography: imaging setup and application” (PhD, Medical University of Vienna, 2017).
- Tschackad Kamali-Dolatabadi, “ Spatially resolved molecular sensitive imaging with optical coherence tomography utilizing coherent anti-Stokes Raman scattering“ (PhD, Medical University of Vienna, 2016)
- Liu, Mengyang, “Multimodal photoacoustic and optical coherence tomography imaging,” (PhD, Medical University of Vienna, 2015)
- Abhishek Kumar, "Digital adaptive optics for achieving space-invariant lateral resolution in optical coherence tomography" (PhD, Medical University of Vienna, 2015)
- Daniel Josef Fechtig, "Development and improvement of parallel Optical Coherence Tomography modalities for biomedical imaging" (PhD, Medical University of Vienna, 2015)
- Cédric Steve Blatter, "Functional swept source optical coherence tomography" (PhD, Medical University of Vienna, 2013)
- Amardeep Sönke Georg Singh, "Functional retinal optical coherence tomography advancing data analysis and exploring holographic imaging concepts" (PhD, Medical University of Vienna, 2012)
- Tilman Schmoll, "Optical Coherence Tomography of Tissue Physiology" (PhD, Medical University of Vienna, 2010)