Abk�rzung zur Hauptnavigation Abk�rzung zu den Newsmeldungen Abk�rzung zu den Topstories  
English Version English Version
  MedUni Wien  trenner  Intranet  trenner  MedUni Wien - Shop  trenner  Universitätsbibliothek  trenner  Universitätsklinikum AKH Wien  trenner
 
Med_Physik.png
 
 
 
Hauptnavigation
  • Home
  • Allgemeine Informationen
    • Team und Kontakt
    • Jobs
    • Projekte für Studierende
    • Geschichtliches
    • Archiv vor 2017
  • Services
  • Studium & Lehre
  • Wissenschaft & Forschung
    • Biophotonics
    • Cardiovascular Engineering
    • Conventional Imaging
    • Magnetic Resonance
    • Medical Additive Manufacturing
    • Neuroprosthetics & Rehabilitation Engineering
    • Quantitative Imaging and Medical Physics
    • Research Partners
 
Wissenschaft & Forschung / Magnetic Resonance / Skeletal muscle MRS and MRI
 
Subnavigation
  • Biophotonics
  • Cardiovascular Engineering
  • Conventional Imaging
  • Magnetic Resonance
    • Body Spectroscopy and Imaging
    • Motion detection and Correction
    • Pulse Sequences and Image Reconstruction
    • Micro-imaging and microscopy
    • Radio Frequency Coils & MR Hardware
    • Skeletal muscle MRS and MRI
  • Medical Additive Manufacturing
  • Neuroprosthetics & Rehabilitation Engineering
  • Quantitative Imaging and Medical Physics
  • Research Partners


Inhaltsbereich

Skeletal muscle MRS and MRI

We are specialised in dynamic in vivo multi-nuclear Magnetic Resonance Spectroscopy and Imaging. Our focus is on skeletal muscle energy metabolism and perfusion.

Skeletal muscle phosphate kinetics

Skeletal muscle can ramp up its energy turnover by orders of magnitude. Exercise recovery during ³¹P MRS is uniquely suited to study cellular mitochondrial function, glycolysis and proton kinetics in situ. We develop and combine imaging and spectroscopy techniques and dedicated RF coils to locally measure ATP, phosphocreatine (PCr) and pH directly in the exercising muscle in real time.



Skeletal muscle perfusion

Blood flow and capillary perfusion deliver nutrients and oxygen to the muscle and help dispose metabolic products. Perfusion deficits or ischaemia can cause severe disorders and lead to immobilsation, infection and reduced healing. Transient ischaemia can be induced safely by pressure cuffs. Perfusion rates can change dramatically between these impaired states and maximal exercise in healthy tissue.
Arterial spin labeling (ASL) tags and traces arterial blood spins. Our developed sequences generate perfusion data every few seconds allowing time-resolved measurements without external contrast agents, simultaneously with metabolic information from spectroscopy.

Skeletal muscle perfusion

We have investigated and applied measurements of intracellular muscle fat (IMCL) which are sensitive markers of insulin sensitivity, impairment of which is a precursor and feature of diabetes mellitus. Muscle glycogen is stored and used as a sugar reservoir under high work load and anaerobic metabolism. Under these hypoxic conditions, lactate accumulates and can be quantified using special spectral editing techniques.

Researcher Groups

Schmid group | Meyerspeer group

 
Drucken
 
 
© MedUni Wien | Impressum | Nutzungsbedingungen | Datenschutzerklärung | Barrierefreiheit |Kontakt